Table 3.

Relationship between biomarkers and outcome measures

Factor		N	Complete response rate (%)	1-year OS (%) (95% CI)	1-year PFS (%) (95% CI)
IPI score
0–1		25	72	95.8 (73.9, 99.4)	95.8 (73.9, 99.4)
2–4		44	43	62.8 (46.6, 75.3)	54.0 (38.1, 67.4)
OR/HR3			3.38 (1.06. 11.47)	0.40 (0.15, 1.09)	0.39 (0.16, 0.97)
P-value			0.0261	0.0282	0.0152
CXCL13
< median		35	74	88.0 (71.2, 95.3)	85.0 (67.6, 93.5)
> median		34	32	61.3 (42.8, 75.4)	52.9 (35.1, 67.9)
OR/HR3			6.04 (1.90, 19.68)	0.31 (0.13, 0.74)	0.41 (0.19, 0.89)
P-value			<0.0011	0.0082	0.0242
sCD27
< median		34	53	70.1 (51.5, 82.6)	61.1 (42.5, 75.3)
> median		34	56	81.9 (64.1, 91.4)	79.1 (61.1, 89.5)
OR/HR3			0.89 (0.31, 2.56)	1.78 (0.78, 4.08)	0.77 (0.83, 3.78)
P-value			1.0001	0.1712	0.1412
sCD23
< median		34	47	82.1 (64.5, 91.6)	73.1 (54.7, 85.0)
> median		35	60	68.0 (49.6, 80.8)	65.2 (46.9, 78.5)
OR/HR3			0.59 (0.20, 1.71)	0.43 (0.18, 1.01)	0.64 (0.31, 1.35)
P-value			0.3381	0.0512	0.2452
sCD30
< median		35	60	69.5 (50.7, 82.3)	58.0 (39.6, 72.7)
> median		34	47	79.8 (62.2, 89.8)	79.8 (62.2, 89.8)
OR/HR3			1.69 (0.59, 4.88)	1.59 (0.71, 3.56)	1.62 (0.77, 3.41)
P-value			0.3381	0.2612	0.2072
IL-6
< median		34	68	90.8 (74.1, 96.9)	85.0 (67.7, 93.5)
> median		34	41	61.2 (42.6, 75.3)	55.1 (36.9, 70.1)
OR/HR3			2.99 (1.00, 9.08)	0.26 (0.10, 0.64)	0.34 (0.15, 0.76)
P-value			0.0511	0.0042	0.0082
IL-10
Undetectable		31	71	93.3 (75.8, 98.3)	90.1 (72.3, 96.7)
Detectable		38	39	60.0 (42.6, 73.6)	52.6 (35.8, 67.0)
OR/HR3			3.75 (1.23, 11.77)	0.25 (0.09–0.67))	0.31 (0.13, 0.74)
P-value			0.0151	0.0062	0.0082
LDH
< median		30	60	85.9 (66.7, 94.5)	79.6 (60.1, 90.3)
> median		30	40	60.0 (40.5, 75.0)	53.3 (34.3, 69.1)
OR/HR3			2.25 (0.71, 7.18)	0.41, 0.17, 0.98)	0.45 (0.20, 0.98)
P-value			0.1961	0.0442	0.0462

¹Fisher’s exact test

²log rank test

³Odds ratio (OR) and 95% confidence interval for complete responses; hazard ratio (HR) and 95% confidence interval for OS and PFS (unadjusted)