Table 1.
Summary of 16S rRNA sequencing and qPCR analyses of colonic microbiota variations in colorectal cancer
| Variation in CRC | Phyla | Genus/species | Population | Ref. |
| Fecal flora | ||||
| ↑ | Enterococcus Faecalis | 20 CRC/17 C | [73] | |
| ↑ | Proteobacteria | Porphyromonas/Escherichia/Shigella Enterococcus/Streptococcus/Peptostreptococcus | 46 CRC/56 C | [62] |
| Bacteroides fragilis | ||||
| ↑ | Bacteroides/Prevotella | 60 CRC/119 C | [61] | |
| ↑ | Peptostreptococcus/Mogibacterium | 21 CRC/22 C | [18] | |
| Anaerococcus/Slakia/Paraprevotella | ||||
| Anaerotruncus/Collinsella/Desulfovibrio | ||||
| Eubacterium/Porphyromonas | ||||
| ↑ | Bacteroidetes | Atopobium/Porphyromonas | 47 CRC/94 C | [63] |
| Fusobacteria | Fusobacterium | |||
| ↑ | Fusobacteria | Fusobacterium/Bacteroides | 19 CRC/20 C | [64] |
| ↑ | Bacteroides/Fusobacterium | 46 CRC/63 C | [214] | |
| Alistipes/Escherichia/Parvimonas/Bilophila | ||||
| ↓ | Faecalibacterium prauznitsii | 20 CRC/17 C | [73] | |
| ↓ | Bacteroidetes | Bacteroides vulgatus/Bacteroides uniformis | 46 CRC/56 C | [62] |
| Roseburia/Butyrate-producing bacteria | ||||
| ↓ | Faecalibacterium prauznitsii/Roseburia | 19 CRC/20 C | [64] | |
| ↓ | Firmicutes (clostridia) | Ruminococcus | 47 CRC/94 C | [63] |
| ↓ | Ruminococcus/Bifidobacterium/Streptococcus | 46 CRC/63 C | [214] | |
| Tumor-associated flora | ||||
| ↑ | Bacteroidetes | Coriobacteriae/Roseburia | 6 CRC/6 AM | [14] |
| Fusobacterium/Faecalibacterium | ||||
| Butyrate-producing bacteria | ||||
| ↑ | Bacteroides | 22 CRC/22 C | [61] | |
| ↑ | Fusobacterium | 95 CRC'95 AM | [106] | |
| ↑ | Bacteroidetes | Bacteroides/Prevotella/Streptococcus | 27 CRC | [18] |
| Fusobacteria | Fusobacterium/Peptostreptococcus | 27 intestinal lumen | ||
| Proteobacteria | Morganella/Porphyromonas | |||
| ↑ | Fusobacterium | 55 CRC/55 AM | [109] | |
| ↓ | Firmicutes | Shigella/Citrobacter/Serratia/Salmonella | 6 CRC/6 AM | [14] |
| ↓ | Firmicutes | Lactobacillus/Roseburia/Pseudobutyrivibrio | 27 CRC | [18] |
| 27 intestinal lumen | ||||
| ↓ | Bacteroidetes | 95 CRC/95 AM | [106] | |
| Firmicutes (clostridia) | ||||
| Mucosa-associated flora | ||||
| ↑ | Fusobacterium/Porphyromonas | 32 CRC | [18] | |
| Peptostreptococcaceae/Gemella | 22 C (swab) | |||
| Mogibacterium/Klebsiella | ||||
| ↓ | Faecalibacterium/Blautia/Anaeroslipes | 32 CRC | [18] | |
| Lachospira/Bifidobacterium | 22 C (swab) | |||
CRC: Colorectal cancer; C: Control patients; AM: Adjacent tumor, normal mucosa of patients with CRC.