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. 2015 Jun 12;23(2):197–206. doi: 10.1038/cdd.2015.81

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The MRN complex is required for MYCN-dependent proliferation in neuron-like cells. (a) WB analysis of the expression of the indicated proteins and (b) cells counts performed in MYCN+/− cells in which NBS1 was downregulated by two different IPTG-inducible shRNAs (shNBS1-35 and sh-NBS-36). (c) Cell counts performed on the MYCN+/- cells treated with mirin or vehicle (DMSO). (d) Cell death was monitored by trypan blue exclusion assay in MYCN+/− cells with or without mirin treatment and by detection of the cleaved form of PARP1 via immunoblot (cPARP in the inset)