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. 2015 Jun 12;23(2):197–206. doi: 10.1038/cdd.2015.81

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MYCN induces replication stress. (a) WB analysis of the expression of the indicated proteins and phosphoepitopes in MYCN+/− cells at various time points. (b) WB analysis of RPA32 protein expression in total extracts and in the chromatin-bound fractions, in MYCN+/− cells. Histone H3 and β tubulin were used as positive and negative controls of chromatin fraction, respectively. The ponceau staining was used as the loading control. (c) Neutral comet assay of MYCN+/− cells in basal condition. (d) WB analysis of the expression of the indicated protein in MYCN+/− cells untreated or treated with hydroxyurea (HU, 1 mM). (***P<0.005)