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. 2015 Jul 17;23(2):253–260. doi: 10.1038/cdd.2015.92

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Similar to MLKL, RIPK1 and RIPK3 translocate to the nucleus, and their function is required for MLKL nuclear translocation. (a and b) Western analyses of the nuclear accumulation of MLKL, RIPK1, and RIPK3 in (a) HT29 cells and (b) MEFs after TBZ treatment. (c) Co-immunoprecipitation of RIPK1 and RIPK3 with MLKL from the cytosolic and nuclear extracts of HT29 cells. (d and e) Western analyses of the impact of the knockdown (d) of RIPK1 expression in HT29 cells and (e) of RIPK3 expression in MEFs on the co-translocation of the three proteins to the nucleus (CT, control; K/D, knockdown). (f) Western analysis of the effect of Nec-1 (5 μM) on TBZ-induced nuclear translocation of MLKL