Table 2.
Characteristics of Participants at Enrolment of Included Studies Evaluating ACT vs Non-ACT in Pregnancy, Asia and Africa, 1995–2009
| Study | Age |
Gestational Age |
Fever |
Maternal Weight |
Gravidity |
Parasitemia |
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ACT | Non-ACT | ACT | Non-ACT | ACT | Non-ACT | ACT | Non-ACT | ACT | Non-ACT | ACT | Non-ACT | |
| Bounyasong [10] | Mean 26.1 y, sd 7.5, n = 28 | Mean 27.2 y, sd 7.5, n = 29 | Mean 26.7 wks, sd 7.6, n = 28 | Mean 27.4 wks, sd 7.6, n = 29 | Mean 40.4°C, sd 0.6, n = 28 | Mean 40.6°C, sd 0.6, n = 29 | Mean 57.1 kga, sd 4.1, n = 28 | Mean 58.7 kga, sd 4.1, n = 29 | Mean 2.4, sd 0.6, n = 28 | Mean 2.6, sd 0.6, n = 29 | Mean1330/200 WBC, sd 209, n = 28 | Mean 1313/200 WBC, sd 209, n = 29 |
| Kalilani [11] | Median 20 y, IQR 17–24 | Median 20 y, IQR 18–23 | Median 22 wks, IQR 20–24 | Median 24 wks, IQR 20–24 | >37.5°C: 2 of 49 (4.1%) | >37.5°C: 3 of 49 (6.1%) | Mean 52.9 kg, sd 5.9, n = 47 | Mean 52.2 kg, sd 6.1, n = 47 | Median 1, IQR 1–3 PG: 28 of 47 (59.6%) | Median 1, IQR 1–3 PG: 25 of 47 (53.1%) | Geometric mean 687/µL, range 120–4260 | Geometric mean 1184/µL, range 150–22 500 |
| McGready [13] | Median 24 y, range 15–37, n = 66 | Median 23 y, range 16–36, n = 42 | Median 24 wks, range 12–40, n = 66 | Median 24 wks, range 15–38, n = 42 | >37.5°C: 10 of 66 (15.2%) | >37.5°C: 9 of 42 (21.4%) | Median 48 kg, range 36–68, n = 66 | Median 50 kg, range 41–67, n = 42 | PG: 18 of 66 (27.3%) | PG: 12 of 42 (28.6%) | Median 11 651/µL, range 32–241 127, n = 66 |
Median 19 086/ µL, range 79–149 389, n = 42 |
| McGready [12] | Mean 26 y, sd 6, n = 39 | Mean 26 y, sd 7, n = 42 | Mean 21 wks, sd 5.3, n = 39 | Mean 21 wks, sd 4.5, n = 42 | Fever b 7 of 39 (17.9%) |
Fever b 7 of 42 (16.7%) |
Mean 49 kg, sd 7, n = 39 | Mean 50 kg, sd 7, n = 42 | PG: 12 of 39 (30.8%) | PG: 11 of 42 (26.2%) | Geometric mean 2596/ µL, range 33–123 027 | Geometric mean 2084/µL, range 33–109 648 |
| Mutabingwa [14] | Median 21 y, IQR 19–26, n = 83 | Median 20 y, IQR 19–25, n = 80 | Median 6 mo, IQR 5–7, n = 83 | Median 7 mo, IQR 5–7, n = 80 | NR | NR | NR | NR | PG: 20 of 34 (59%) | PG: 14 of 38 (37%) |
Median181/200 WBC range 62–628, n = 83 |
Median 25/200 WBC range 51–578, n = 80 |
| Piola [9] | Mean 22.5 y, range 15–38, n = 152 | Mean 22.6 y, range 17–38, n = 152 | Mean 22.3 wks, range 9–38, n = 152 | Mean 24.7 wks, range 10–39, n = 152 | >37.5°C: 35 of 152 (23.0%) |
>37.5°C: 30 of 152 (19.7%) |
Mean 58 kg, sd 10, n = 152 | Mean 58 kg, sd 10, n = 152 | Median 2, range 1–8 | Median 2, range 1–7 | Geometric mean 1418/µL, sd 4727, n = 152 | Geometric mean 1995/µL, sd 9771, n = 152 |
Abbreviations: ACT, artemisinin-based combination therapy; IQR, interquartile range; kg, kilogram; NR, not reported; PG, primigravidae; sd, standard deviation; WBC, white blood cells.
a Bounyasong [10]: Weight before pregnancy.
b Fever threshold not defined.