Table 3.
Comparison of clinical features according to year of diagnosis of thyroid cancer
| Variable | Year of diagnosis |
p value | |||
|---|---|---|---|---|---|
| 1995 – 1999 | 2000 – 2004 | 2005 – 2009 | 2010 – 2013 | ||
| Patients, n | 6 | 24 | 39 | 57 | – |
| Median age, years | 18 | 17 | 17 | 17 | 0.97 |
| Female, n (%) | 6 (100) | 22 (92) | 35 (90) | 47 (82) | 0.44 |
| History of radiation, n (%) | 0 | 1 (4) | 0 | 3 (5) | 0.50 |
| Histology, n (%) | 4 (67) | 23 (96) | 37 (95) | 51 (89) | 0.07 |
| Papillary | |||||
| Classic | 3 (50) | 23 (96) | 32 (82) | 44 (77) | |
| Follicular | 1 (17) | 0 | 2 (5) | 0 | |
| Diffuse sclerosing | 0 | 0 | 2 (5) | 6 (10) | |
| Cribriform-morular | 0 | 0 | 1 (3) | 1 (2) | |
| Follicular | 2 (33) | 1 (4) | 2 (5) | 3 (5) | |
| Medullary | 0 | 0 | 0 | 1 (2) | |
| Poorly differentiated | 0 | 0 | 0 | 2 (4) | |
| Mass found by palpation, n (%) | 6 (100) | 22 (92) | 27 (69) | 32 (56) | 0.03 |
| Median palpable mass size1, cm | 2.4 | 2.6 | 2.3 | 2.8 | 0.38 |
| Median mass size, cm | 2.4 | 2.6 | 1.5 | 2.1 | 0.042 |
1
Masses found by palpation were included for this calculation.
2
The Kruskal-Wallis test was used for non-parametric variables comparing more than two groups, and the median mass size was significantly different between the four groups. According to the Mann-Whitney U test and Bonferroni correction for post hoc analysis, the difference was significant between the two groups from 2000 – 2004 and 2005 – 2009.