Figure 2.
Levels of dA-AL-I adducts in 29 nontumour renal cortex samples from renal cell carcinoma cases of the Czech Republic (CZ), United Kingdom (UK), Russian Federation (RU), and Romania (RO). The dot line indicates the limit of quantification (LOQ) value (0.3 adducts per 108 DNA bases). Levels of adducts in Romanian samples were measured in duplicate: on DNA samples extracted with the standard Autopure (Qiagen) protocol, and on DNA samples extracted using a phenol/chloroform protocol. Using the latest samples, cases from Romania harboured dA-AL-I at levels ranging from 0.7 to 27 adducts per 108 DNA bases. The levels of adducts in all other cases were below the LOQ value.