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. 2016 Jan 8;2(1):e000093. doi: 10.1136/rmdopen-2015-000093

Figure 1.

Figure 1

The effect of 3,4-dichloropropionaniline (DCPA) treatment by continuous-release subcutaneous pellets on collagen-induced arthritis (CIA) as measured by the arthritic index. The data were gathered by a blinded observer. n=4 for untreated controls; in the CIA animals n=11 for animals treated with 0 mg/kg/day DCPA; n=10 for animals treated with 10.5 mg/kg/day DCPA; n=8 for animals treated with 21 mg/kg/day. (A) Median effect relative to CIA animals treated with 0 mg/kg/day DCPA (blue; open circles) and untreated controls (red; closed square). There is a trend toward efficacy at intermediate times in CIA animals treated with 10.5 mg/kg/day DCPA (green; closed circles) but only the CIA animals treated with 21 mg/kg/day DCPA (yellow; closed triangles) had a durable effect. (B) Scatter plot showing the arthritis scores at day 37. This demonstrates that >50% animals in the CIA animals treated with 0 mg/kg/day (blue; open circles) and 10.5 mg/kg/day DCPA (green; closed circles) show arthritis scores that exceed the mean and several animals showed the maximum arthritis score, whereas a majority of the animals /21 mg/kg/day DCPA (yellow; closed triangles) showed no or minimal arthritis scores. (C) Paw thickness, mean±SEM, for 4 control, 11 untreated CIA, and 8 high-dose DCPA/CIA animals. The difference between control and CIA animals is significant (*, p<0.05); the high-dose DCPA animals are not different relative to the other groups (ns).