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. 2016 Jan 8;2(1):e000093. doi: 10.1136/rmdopen-2015-000093

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Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

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Model of the key functions of 3,4-dichloropropionaniline (DCPA) responsible for inhibiting collagen-induced acute arthritis. Independently of cytokines, the calcium-release activated calcium-inhibitor DCPA blocks maturation of osteoclasts, and probably also of T cells, contributing to arthritic destruction.