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. 2015 Nov 3;59(1):44–60. doi: 10.1021/acs.jmedchem.5b01303

Figure 4.

Figure 4

[35S]GTPγS assay depicting the NAM effect of increasing concentrations of 20. Mean % increases in [35S]GTPγS binding to mouse brain membranes induced by CP55,940 in the presence of DMSO (n = 12) or 100 nM or 1 μM of 20 (n = 6) or 1 μM of 1 (n = 4). The mean Emax value of CP55,940 with its 95% confidence interval in parentheses is 94.3% (85.8–102.8%) in the presence of DMSO, 71.7% (65.3–78.1%) in the presence of 100 nM of 20, 11.2% (5.6–16.8%) in the presence of 1 μM of 20, and 32.4% (24.0–40.8%) in the presence of 1 μM of 1. Vertical lines show SEM values.