Scheme 1. Synthesis of Piperidinyl Phenethylamine 8.
Reagents and conditions: (a) piperidine, K2CO3, anhyd NMP, 135 °C, 12 h; (b) CH3NO2, NH4OAc, reflux, 2 h; (c) (i) NaBH4, MeOH, 5 °C to rt, 2 h; (ii) NiCl2·6H2O, NaBH4, THF:MeOH (95:5), 0 °C, 3 h.
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.