Scheme 2. Synthesis of Substituted Indole-2-carboxylates 15a, 15b, and 15c.
Reagent and conditions: (a) NaNO2, HCl, 0 °C, 1 h; (b) NaOEt, EtOH, 12 h, reflux; (c) CH3COONa, EtOH, 0 °C, 3 h; (d) 20% H2SO4, EtOH, reflux, 24 h.
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