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. 2015 Nov 9;4(11):680–689. doi: 10.1002/psp4.12039

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© 2015 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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PopPK model diagram for vismodegib. GI, gastrointestinal tract; D_unbound, unbound drug; AAG, alpha‐1‐acid glycoprotein (unbound); D‐AAG, the bound complexes of drug and alpha‐1‐acid glycoprotein; k_a, first‐order rate constant; F, relative bioavailability; KD_AAG, dissociation constant for binding of drug with AAG; CL_unbound, the apparent clearance of unbound vismodegib.