Table 4.
Number of metabolites in: | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
Pathway name | SMPDB IDa | KEGG IDb | Drug | Race | Direction of change | Pathwayc | Groupd | Overlappinge | Names of overlapping metabolites | P valuef |
Purine metabolism | SMP00050 | map00230 | HCTZ | All | Increase | 45 | 128 | 4 | Uric acid, hypoxanthine, adenosine‐5‐phosphate, adenosine | <1 × 10−9 |
Alpha linolenic acid and linoleic acid metabolism | SMP00018 | map00592 | ATEN | All | Decrease | 17 | 98 | 2 | Linoleic acid, arachidonic acid | 1.09 × 10−08 |
Purine metabolism | SMP00050 | map00230 | HCTZ | White | Increase | 45 | 139 | 4 | Uric acid, hypoxanthine, adenosine‐5‐phosphate, adenosine | 2.24 × 10−08 |
Alpha linolenic acid and linoleic acid metabolism | SMP00018 | map00592 | ATEN | White | Decrease | 17 | 88 | 2 | Linoleic acid, arachidonic acid | 7.57 × 10−07 |
Purine metabolism | SMP00050 | map00230 | HCTZ | Black | Increase | 45 | 72 | 3 | Uric acid, hypoxanthine, adenosine monophosphate | 5.12 × 10−05 |
Galactose metabolism | SMP00043 | map00052 | HCTZ | All | Increase | 25 | 128 | 8 | Glucose, glycerol, myo‐inositol, fructose, sorbitol, glucose 1‐phosphate, sucrose, maltotriose | 0.0003 |
Gluconeogenesis | SMP00128 | map00010 | HCTZ | All | Increase | 27 | 128 | 6 | Glucose, lactic acid, pyruvic acid, glucose 1‐phosphate, alpha ketoglutaric acid, 3‐phosphoglycerate | 0.0004 |
Glycerolipid metabolism | SMP00039 | map00561 | ATEN | All | Decrease | 19 | 98 | 6 | Glycerol, palmitic acid, glyceric acid, glycerol‐3‐phosphate, 3‐phosphoglycerate, 2‐monopalmitin | 0.0005 |
Glycolysis | SMP00040 | map00010 | HCTZ | All | Increase | 21 | 128 | 4 | Glucose, pyruvic acid, glucose 1‐phosphate, 3‐phosphoglycerate | 0.0009 |
Glycolysis | SMP00040 | map00010 | HCTZ | White | Increase | 21 | 139 | 4 | Glucose, pyruvic acid, glucose 1‐phosphate, 3‐phosphoglycerate | 0.0013 |
Gluconeogenesis | SMP00128 | map00010 | HCTZ | White | Increase | 27 | 139 | 6 | Glucose, lactic acid, pyruvic acid, glucose 1‐phosphate, alpha ketoglutaric acid, 3‐phosphoglycerate | 0.0023 |
Glycerolipid metabolism | SMP00039 | map00561 | ATEN | White | Decrease | 19 | 88 | 3 | Palmitic acid, glyceric acid, glycerol‐3‐phosphate | 0.0025 |
Fatty acid biosynthesis | SMP00456 | ATEN | All | Decrease | 32 | 98 | 5 | Palmitic acid, dodecanoic acid, capric acid, myristic acid, caprylic acid | 0.0055 | |
Lactose synthesis | SMP00444 | HCTZ | All | Increase | 11 | 128 | 2 | Glucose, glucose 1‐phosphate | 0.0065 | |
Fatty acid biosynthesis | SMP00456 | ATEN | White | Decrease | 32 | 88 | 2 | Palmitic acid, myristic acid | 0.0093 | |
Plasmalogen synthesis | SMP00479 | HCTZ | White | Increase | 22 | 139 | 3 | Stearic acid, octadecanol, 1‐hexadecanol | 0.0101 | |
Tryptophan metabolism | SMP00063 | map00380 | HCTZ | White | Increase | 34 | 139 | 3 | Tryptophan, indole‐3‐acetate, kynurenine | 0.0133 |
Galactose metabolism | SMP00043 | map00052 | HCTZ | White | Increase | 25 | 139 | 8 | Glucose, glycerol, myo‐inositol, fructose, sorbitol, glucose 1‐phosphate, sucrose, maltotriose | 0.0146 |
Lactose synthesis | SMP00444 | HCTZ | White | Increase | 11 | 139 | 2 | Glucose, glucose 1‐phosphate | 0.0258 | |
Urea cycle | SMP00059 | map00330 | HCTZ | All | Increase | 20 | 128 | 8 | Alanine, urea, glutamic acid, citrulline, pyruvic acid, fumaric acid, alpha ketoglutaric acid, adenosine monophosphate | 0.0377 |
Small Molecule Pathway Database ID.
Kyoto Encyclopedia of Genes and Genomes ID.
Number of metabolites in pathway.
Number of metabolites studied.
Number of metabolites studied that also overlapped with metabolites in the pathway.
Bonferroni corrected P value.