Table 4.

Results from correlated Lancaster pathway analysis signature of exposure

						Number of metabolites in:
Pathway name	SMPDB IDa	KEGG IDb	Drug	Race	Direction of change	Pathwayc	Groupd	Overlappinge	Names of overlapping metabolites	P valuef
Purine metabolism	SMP00050	map00230	HCTZ	All	Increase	45	128	4	Uric acid, hypoxanthine, adenosine‐5‐phosphate, adenosine	<1 × 10−9
Alpha linolenic acid and linoleic acid metabolism	SMP00018	map00592	ATEN	All	Decrease	17	98	2	Linoleic acid, arachidonic acid	1.09 × 10−08
Purine metabolism	SMP00050	map00230	HCTZ	White	Increase	45	139	4	Uric acid, hypoxanthine, adenosine‐5‐phosphate, adenosine	2.24 × 10−08
Alpha linolenic acid and linoleic acid metabolism	SMP00018	map00592	ATEN	White	Decrease	17	88	2	Linoleic acid, arachidonic acid	7.57 × 10−07
Purine metabolism	SMP00050	map00230	HCTZ	Black	Increase	45	72	3	Uric acid, hypoxanthine, adenosine monophosphate	5.12 × 10−05
Galactose metabolism	SMP00043	map00052	HCTZ	All	Increase	25	128	8	Glucose, glycerol, myo‐inositol, fructose, sorbitol, glucose 1‐phosphate, sucrose, maltotriose	0.0003
Gluconeogenesis	SMP00128	map00010	HCTZ	All	Increase	27	128	6	Glucose, lactic acid, pyruvic acid, glucose 1‐phosphate, alpha ketoglutaric acid, 3‐phosphoglycerate	0.0004
Glycerolipid metabolism	SMP00039	map00561	ATEN	All	Decrease	19	98	6	Glycerol, palmitic acid, glyceric acid, glycerol‐3‐phosphate, 3‐phosphoglycerate, 2‐monopalmitin	0.0005
Glycolysis	SMP00040	map00010	HCTZ	All	Increase	21	128	4	Glucose, pyruvic acid, glucose 1‐phosphate, 3‐phosphoglycerate	0.0009
Glycolysis	SMP00040	map00010	HCTZ	White	Increase	21	139	4	Glucose, pyruvic acid, glucose 1‐phosphate, 3‐phosphoglycerate	0.0013
Gluconeogenesis	SMP00128	map00010	HCTZ	White	Increase	27	139	6	Glucose, lactic acid, pyruvic acid, glucose 1‐phosphate, alpha ketoglutaric acid, 3‐phosphoglycerate	0.0023
Glycerolipid metabolism	SMP00039	map00561	ATEN	White	Decrease	19	88	3	Palmitic acid, glyceric acid, glycerol‐3‐phosphate	0.0025
Fatty acid biosynthesis	SMP00456		ATEN	All	Decrease	32	98	5	Palmitic acid, dodecanoic acid, capric acid, myristic acid, caprylic acid	0.0055
Lactose synthesis	SMP00444		HCTZ	All	Increase	11	128	2	Glucose, glucose 1‐phosphate	0.0065
Fatty acid biosynthesis	SMP00456		ATEN	White	Decrease	32	88	2	Palmitic acid, myristic acid	0.0093
Plasmalogen synthesis	SMP00479		HCTZ	White	Increase	22	139	3	Stearic acid, octadecanol, 1‐hexadecanol	0.0101
Tryptophan metabolism	SMP00063	map00380	HCTZ	White	Increase	34	139	3	Tryptophan, indole‐3‐acetate, kynurenine	0.0133
Galactose metabolism	SMP00043	map00052	HCTZ	White	Increase	25	139	8	Glucose, glycerol, myo‐inositol, fructose, sorbitol, glucose 1‐phosphate, sucrose, maltotriose	0.0146
Lactose synthesis	SMP00444		HCTZ	White	Increase	11	139	2	Glucose, glucose 1‐phosphate	0.0258
Urea cycle	SMP00059	map00330	HCTZ	All	Increase	20	128	8	Alanine, urea, glutamic acid, citrulline, pyruvic acid, fumaric acid, alpha ketoglutaric acid, adenosine monophosphate	0.0377

^aSmall Molecule Pathway Database ID.

^bKyoto Encyclopedia of Genes and Genomes ID.

^cNumber of metabolites in pathway.

^dNumber of metabolites studied.

^eNumber of metabolites studied that also overlapped with metabolites in the pathway.

^fBonferroni corrected P value.