Scheme 1. Synthetic Routes Facilitating Diversification of Pyridone Scaffold.
Reagents and conditions: (a) 2-methyl-2-butene, NaClO2, NaPO4H2–H2O; (b) HBTU or oxalyl or thionyl chloride, NH2R1; (c) HCl; (d) NHR2R3, Δ; (e) R1C1NH2C2NH2, MeOH, Δ.
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