Table 3. Selectivity over JAK Family Members.

Cmpd	TMLR Ki (μM)a	wtEGFR Select.b	JAK1 Select.c	JAK2 Select.d
13	0.019	57	9	0.5
19	0.004	213	3	2
35	0.026	16	42	0.9
36	0.031	> 80	104	4
27	0.058	42	2	0.2
37	0.088	27	6	0.3

^aK_i data are an average of at least two independent experiments.

^bRatio of wtEGFR K_iapp over EGFR(TMLR) K_iapp.

^cRatio of JAK1 K_iapp over EGFR(TMLR) K_iapp.

^dRatio of JAK2 K_iapp over EGFR(TMLR) K_iapp.