Figure 3.

(a) Agonist 14 was stable in rat plasma after 4 h (pH 7.4, 37 °C, initial concentration 1 μM) compared to peptides 1 and 6. The plasma samples were analyzed by LCMS (n = 3). (b) Agonists 1 and 14 (AY77) activate Ca²⁺ release via PAR2. Experiments were performed in CHO-hPAR2 cells (solid lines) versus CHO cells (PAR2^–/–, dotted lines), n ≥ 3. Each data point represents mean ± SEM.