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PAR2-activated chemotaxis in MDA-MB-231 breast cancer cells. Compounds 1 and 14 (100 nM) induced chemotaxis in a transwell migration assay. Preincubating cells with PAR2 antibody SAM11 (1 μg/mL) 30 min prior to agonist addition resulted in inhibition of chemotaxis. The chemotactic index is the ratio of agonist to random migration (24 h) through a 5 μm membrane, mean ± SEM, ***p < 0.001.
