CYM inhibits but does not prevent aGVHD. (a) CYM treatment could dramatically prolong the survival of GVHD compared with control treatment in mice (n=10 per group; ***P<0.0001). (b, c) Body weight loss of GVHD mice and GVHD scores (P<0.01) were reduced by administration of CYM. (d) CYM administration dramatically reduced GVHD characteristics of target organs (×400, liver; ×200, lung; ×200, intestine). The data are representative of three independent experiments, each using 10 mice per group. Data are shown as the mean±s.e.m. aGVHD, acute graft-versus-host disease.