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Evaluation of metabolic stability of thiazole compound 5, verapamil, and warfarin in human liver microsomes.
| Compound/Drug Tested | NADPH-dependent CLint1 (μL/min/mg) |
NADPH-dependent T1/22 (min) |
NADPH-free CLint (μL/min/mg) |
NADPH-free T1/2 (min) |
|---|---|---|---|---|
| 5 | 3.7 | >240 | 0.0 | >240 |
| Verapamil | 213 | 10.8 | 0.0 | >240 |
| Warfarin | 0.0 | >240 | 0.0 | >240 |
CLint = microsomal intrinsic clearance
T1/2 = half-life
