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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: Clin Sci (Lond). 2015 Aug;129(3):217–234. doi: 10.1042/CS20140714

Figure 2. PECAM-1-mediated signaling pathways through interactions between phosphorylated tyrosine residues in the cytoplasmic domain and SHP-2.

Figure 2

Phosphorylated tyrosine residues in exon 13 (Y663) and exon 14 (Y686) serve as binding site for SHP-2 phosphatase [187], and bound SHP-2 attenuates EC migration by inhibition of MAPK/ERKs signaling pathway [44].