Figure 2.

Divergence of the Identified Core Haplotypes at TLR10, TLR1, and TLR6

(A) Neighbor-joining tree on the inferred sequences of seven modern human core haplotypes (III–IX), and the Neandertal (I), Denisovan (II), orangutan, and chimpanzee genome sequences. Bootstrap values (1,000 replicates) for the topology are provided in blue squares at each node. The pie charts show the frequency in the four continental population groups of each modern human core haplotype. Next to each pie chart, the frequency of haplotypes among 1000 Genomes individuals assigned to the corresponding core haplotype is displayed. For core haplotype-defining positions in each branch, see Table S2.

(B) Pair-wise average nucleotide distance between haplotypes in core haplotypes.