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. 2015 Dec 31;98(1):45–57. doi: 10.1016/j.ajhg.2015.11.017

Figure 3.

Figure 3

Familial IQ Decrement in 16p11.2 Deletion and Duplication Families

(A) Density plots of FSIQ for deletion families (A) and duplication families (B) from the entire Simons VIP cohort. The significant decrement between parents carrying a 16p11.2 deletion and inherited-deletion probands (p = 6 × 10−3, Student’s t test) and between parents carrying a 16p11.2 duplication and inherited-duplication probands (p = 3.89 × 10−6, t test), shown in the third panels of (A) and (B), suggest that factors other than the 16p11.2 CNV contribute to FSIQ decrement.