Figure 3.
Paternal Age and De Novo Events
(A) Paternal age for de novo SNVs and indels. Probands generally have older fathers. The number of variants was significantly correlated with paternal age (Pearson correlation p = 7.9 × 10−9, r = 0.59). The data fit a linear trend (adjusted r2 = 0.34) with advancing paternal age (p = 7.9 × 10−9) such that there are on average 1.4 [0.98, 1.9] de novo mutations for each year of a father’s life. In this study, the father’s age at the time of the child’s birth ranged from 29.4 to 57.9 years.
(B) Paternal age for de novo SNVs and indels within the exome. The number of de novo events detected in each individual is plotted against the father’s age when the individual was born. Shown in blue are siblings, and in red are probands.