Skip to main content
. 2015 Dec 31;98(1):58–74. doi: 10.1016/j.ajhg.2015.11.023

Figure 7.

Figure 7

Functional Analysis of CNS DNase I Hypersensitivity Sites in the DSCAM Deletion

(A) Schematic of the 14 kb DSCAM deletion observed in family 11572. The diagram illustrates the 12 DNase I hypersensitivity sites (HSs) contained within the deletion, as well as the nine sequence intervals encompassing them. These sequence intervals were tested for their potential to direct reporter expression.

(B–D) Bright-field images of representative 48 hpf mosaic zebrafish embryos injected with DSCAM-6 (B), DSCAM-2 (C), and DSCAM-1 (D).

(E–G) tdTomato expression in representative 48 hpf mosaic embryos injected with DSCAM-6 (E), DSCAM-2 (F), and DSCAM-1 (G). Expression was seen in the forebrain (E–G), hindbrain (E–G), midbrain (E and F), spinal cord (F and G), and amacrine cells (F and G).