Figure 6.

Most Interactions Are Cell-Type Specific

(A) Venn diagram showing all significant interactions detected in the five cell types in the intra-TAD space.

(B) Bar graph displaying how many significant intra-TAD interactions are shared between cell types.

(C) Venn diagram showing all significant interactions detected in the five cell types in inter-TAD space.

(D) Bar graph displaying how many significant inter-TAD interactions are shared between cell types.

(E) Diagram of the region under study; genes and TADs are indicated, and the diagram is aligned with the plot in (F).

(F) Plot displaying the average insulation profile (gray) and the average number of significant inter-TAD interactions for loci along the region (blue line, 100 kb window, step size 10 kb). TAD boundaries (minima in insulation profile) display high levels of inter-TAD interactions.

(G) Pie chart showing the number of expressed genes that show significant looping interactions in our datasets.

(H) Pie chart showing the number of non-expressed genes that show significant looping in our datasets.