Table 1. Correlation analysis of transcription factors versus CCL and CCR mRNA expressions. The Pearson’s correlation coefficient (r) between the transcription factors T-bet (Th1), GATA-3 (Th2), and RORC2 (Th17) and the Th1-, Th2-, or Th17-associated CCLs and CCRs were calculated using T lymphocytes stimulated by autologous dendritic cells primed at a MOI=102 with the different A. actinomycetemcomitans serotypes. *p<0.05.
Aggregatibacter actinomycetemcomitans | |||||||
---|---|---|---|---|---|---|---|
Serotype a | Serotype b | Serotype c | |||||
r | p-value | r | p-value | r | p-value | ||
T-bet | CCL2 | -0.606 | 0.394 | 0.918 | 0.082 | -0.487 | 0.513 |
CCL3 | -0.755 | 0.245 | 0.882 | 0.118 | -0.799 | 0.201 | |
CCL5 | -0.485 | 0.515 | 0.931 | 0.049* | -0.682 | 0.318 | |
CCL25 | 0.585 | 0.415 | 0.909 | 0.091 | 0.800 | 0.200 | |
CCR1 | -0.250 | 0.750 | 0.956 | 0.040* | 0.522 | 0.478 | |
CCR2 | -0.800 | 0.200 | 0.934 | 0.046* | -0.762 | 0.238 | |
CCR5 | -0.745 | 0.255 | 0.882 | 0.118 | -0.966 | 0.004 | |
CCR9 | -0.971 | 0.029 | 0.896 | 0.104 | -0.711 | 0.289 | |
GATA-3 | CCL1 | 0.920 | 0.049* | 0.837 | 0.063 | 0.130 | 0.870 |
CCL11 | -0.125 | 0.825 | 0.912 | 0.088 | -0.178 | 0.822 | |
CCL17 | 0.934 | 0.046* | 0.519 | 0.481 | -0.072 | 0.928 | |
CCL28 | -0.231 | 0.769 | 0.304 | 0.696 | 0.251 | 0.749 | |
CCR3 | 0.880 | 0.120 | 0.628 | 0.372 | 0.620 | 0.380 | |
CCR4 | 0.998 | 0.002* | -0.020 | 0.980 | 0.578 | 0.422 | |
CCR8 | 0.932 | 0.048* | 0.940 | 0.060 | 0.956 | 0.044* | |
CCR10 | 0.162 | 0.838 | -0.878 | 0.122 | 0.144 | 0.856 | |
RORC2 | CCL20 | 0.897 | 0.103 | 0.939 | 0.041* | 0.357 | 0.643 |
CCL21 | 0.403 | 0.597 | 0.996 | 0.004* | -0.229 | 0.771 | |
CCR6 | -0.852 | 0.148 | 0.875 | 0.125 | -0.717 | 0.283 | |
CCR7 | 0.998 | 0.002* | 0.970 | 0.030* | 0.909 | 0.091 |