Table 2.
The ratios of plasma trough concentrations during day 2 – week 10 to the last day of treatment (week 12) (pharmacokinetic analysis population)
| Treatment period/Week 12 | Mean (95% CI)
|
||||||||
|---|---|---|---|---|---|---|---|---|---|
| Cariprazine
|
Desmethyl-cariprazine
|
Didesmethyl-cariprazine
|
|||||||
| 3 mg (n=9) | 6 mg (n=8) | 9 mg (n=7) | 3 mg (n=9) | 6 mg (n=8) | 9 mg (n=7) | 3 mg (n=9) | 6 mg (n=8) | 9 mg (n=7) | |
| Day 2/Week 12 | 0.16 (0.08, 0.24)a | 0.10 (0.05, 0.14) | 0.07 (0.05, 0.09) | 0.10 (0.07, 0.14)b | 0.09 (0.05, 0.13) | 0.04 (0.02, 0.06) | 0.002 (0.000, 0.004)a | 0.003 (0.001, 0.005) | 0.002 (0.000, 0.004) |
| Day 3/Week 12 | 1.91 (−1.01, 4.82) | 0.29 (0.19, 0.40) | 0.27 (0.20, 0.35) | 0.49 (0.32, 0.65)a | 0.31 (0.19, 0.42) | 0.22 (0.11, 0.33) | 0.19 (−0.19, 0.58) | 0.02 (0.01, 0.04) | 0.02 (0.01, 0.03) |
| Week 1/Week 12 | 1.05 (0.91, 1.18) | 0.92 (0.72, 1.12) | 0.93 (0.71, 1.14) | 0.89 (0.71, 1.07)a | 0.96 (0.76, 1.16) | 0.73 (0.54, 0.92) | 0.43 (0.00, 0.86) | 0.32 (0.23, 0.42) | 0.26 (0.16, 0.36) |
| Week 2/Week 12 | 1.04 (0.80, 1.27) | 1.15 (0.86, 1.43) | 1.05 (0.75, 1.35) | 1.00 (0.79, 1.22)a | 1.12 (0.84, 1.40) | 1.03 (0.85, 1.20) | 0.99 (0.09, 1.89) | 0.78 (0.57, 1.00) | 0.71 (0.57, 0.85) |
| Week 3/Week 12 | 0.94 (0.75, 1.14) | 1.09 (0.87, 1.31) | 1.04 (0.87, 1.21) | 1.22 (0.91, 1.52)a | 1.03 (0.91, 1.14) | 0.75 (0.56, 0.95) | 1.13 (0.58, 1.69) | 0.89 (0.75, 1.03) | 0.90 (0.72, 1.07) |
| Week 4/Week 12 | 0.79 (0.58, 0.99) | 0.96 (0.79, 1.12) | 1.03 (0.76, 1.30) | 1.02 (0.66, 1.37)a | 1.07 (0.85, 1.28) | 0.83 (0.70, 0.95) | 1.07 (0.71, 1.44) | 0.95 (0.80, 1.11) | 0.93 (0.75, 1.11) |
| Week 5/Week 12 | 1.48 (0.06, 2.89) | 0.97 (0.87, 1.07) | 1.03 (0.70, 1.37) | 1.62 (0.20, 3.04)a | 1.01 (0.78, 1.24) | 0.95 (0.82, 1.09) | 2.23 (−0.49, 4.95) | 0.92 (0.79, 1.06) | 0.95 (0.82, 1.09) |
| Week 6/Week 12 | 1.12 (0.73, 1.51) | 0.99 (0.86, 1.12) | 0.98 (0.65, 1.31) | 1.10 (0.78, 1.42)a | 1.03 (0.87, 1.20) | 1.11 (0.80, 1.43) | 1.14 (0.85, 1.43) | 0.93 (0.74, 1.12) | 1.14 (0.71, 1.57) |
| Week 7/Week 12 | 0.94 (0.79, 1.09) | 1.03 (0.87, 1.20) | 0.96 (0.68, 1.24) | 1.02 (0.78, 1.27)a | 1.10 (0.86, 1.34) | 0.98 (0.78, 1.17) | 1.25 (0.64, 1.86) | 1.04 (0.79, 1.30) | 1.04 (0.71, 1.38) |
| Week 8/Week 12 | 0.81 (0.65, 0.98) | 0.95 (0.76, 1.15) | 0.96 (0.77, 1.16) | 1.01 (0.78, 1.23)a | 1.03 (0.88, 1.19) | 1.01 (0.81, 1.21) | 1.09 (0.84, 1.35) | 1.01 (0.86, 1.16) | 1.03 (0.80, 1.26) |
| Week 10/Week 12 | 1.37 (0.36, 2.38) | 0.94 (0.80, 1.08) | 0.99 (0.69, 1.30) | 1.00 (0.78, 1.21)a | 1.11 (0.89, 1.32) | 0.95 (0.71, 1.20) | 1.03 (0.90, 1.17) | 0.98 (0.83, 1.13) | 1.02 (0.88, 1.16) |
Notes:
a
n=8;
b
n=7.
Abbreviation: CI, confidence interval.