Table 4.
Lesion score of rat gastric tissue pretreated with BM against ethanol-induced gastric damage
| Pretreatment | Hemorrhagic damage (score 0–4) |
Submucosal edema (score 0–4) |
Epithelial cell loss (score 0–3) |
Inflammatory cells (score 0–3) |
Total scoring (scores 14) |
|---|---|---|---|---|---|
| Normal control (vehicle) | 0 | 0 | 0 | 0 | 0 |
| Ethanol ulcer control | 4 (3–4) | 3 (2–4) | 3 (2–3) | 1 (0–3) | 11 (4–14) |
| Omeprazole (20 mg/kg) | 0 (0–2)* | 2 (1–2)* | 1 (0–2)* | 0 (0–1)* | 4 (2–5)* |
| BM (5 mg/kg) | 3 (2–4) | 3 (1–4) | 2 (1–3) | 1 (0–1)* | 9 (2–10) |
| BM (10 mg/kg) | 0 (0–2)* | 1 (0–2)* | 0 (0–1)* | 0 (0–1)* | 2 (0–4)* |
| BM (20 mg/kg) | 1 (1–3)* | 2 (1–3)* | 1 (1–2)* | 1 (0–1)* | 5 (2–8)* |
Notes: Data are expressed as mean ± SEM (n=6),
*
P<0.05; significant vs ulcer control. Statistical analysis was performed using one-way ANOVA followed by Dunnett’s test for multiple comparisons.
Abbreviations: ANOVA, analysis of variance; BM, β-mangostin; SEM, standard error of the mean.