Table 1.
Treatments for sleep disturbances in AD patients
| Treatment of the sleep disorders
|
Treatment for AD
|
|||
|---|---|---|---|---|
| Nonpharmacological | Pharmacological | Others | Improve sleep | Aggravate sleep |
| Behavioral measures | Melatonina | CPAP | Galantamine | Donepezil |
| Stimulus control | Z-hypnotics | Donepezil | Rivastigmine | |
| BLTb | Sedating antidepressant (trazodonea) | Rivastigmine | ||
| Antipsychotics | ||||
| Melatonin receptor agonistsc | ||||
| Hypocretin receptor antagonistc | ||||
| Circadian clock modificationc | ||||
Notes:
a
Therapies with scientific evidence of effectiveness
b
discordant results
c
drugs under development.
Abbreviations: AD, Alzheimer disease; CPAP, continuous pressure airway pressure; BLT, bright light therapy.