Table 6.
Variables associated with nonalcoholic fatty liver disease in women
| Variables | B | OR | 95% CI | P-value |
|---|---|---|---|---|
| Bivariate analysis | ||||
| Age (years) | 0.009 | 1.009 | 0.976–1.044 | 0.589 |
| Waist circumference (cm) | 0.108 | 1.114 | 1.069–1.160 | <0.001 |
| BMI (kg/m2) | 0.217 | 1.242 | 1.122–1.375 | 0.001 |
| Smoking (yes) | 0.091 | 1.095 | 0.478–2.508 | 0.830 |
| eGFR (mL/min/1.73 m2)a | −0.147 | 0.864 | 0.651–1.145 | 0.309 |
| Hypertension (yes) | 1.194 | 3.300 | 1.650–6.600 | 0.001 |
| Office SBP (mmHg)b | 1.082 | 2.950 | 0.347–3.013 | 0.222 |
| Office DBP (mmHg) | 0.017 | 1.017 | 0.985–1.050 | 0.297 |
| 24-hour mean SBP (mmHg) | 0.038 | 1.038 | 1.008–1.070 | 0.013 |
| 24-hour mean DBP (mmHg) | 0.029 | 1.030 | 0.989–1.072 | 0.157 |
| Daytime mean SBP (mmHg) | 0.034 | 1.035 | 1.006–1.064 | 0.019 |
| Daytime mean DBP (mmHg) | 0.021 | 1.021 | 0.984–1.059 | 0.266 |
| Nighttime mean SBP (mmHg) | 0.034 | 1.034 | 1.009–1.061 | 0.008 |
| Nighttime mean DBP (mmHg) | 0.018 | 1.018 | 0.984–1.053 | 0.296 |
| Morning mean SBP (mmHg) | 0.029 | 1.030 | 1.006–1.054 | 0.014 |
| Morning mean DBP (mmHg) | 0.022 | 1.022 | 0.991–1.055 | 0.169 |
| White-coat hypertension (yes) | −0.421 | 0.656 | 0.381–1.129 | 0.128 |
| AST (IU/L) | 0.052 | 1.053 | 0.984–1.128 | 0.137 |
| ALT (IU/L) | 0.051 | 1.052 | 1.007–1.100 | 0.024 |
| GGT (IU/L) | 0.098 | 1.103 | 1.042–1.166 | 0.001 |
| ALP (IU/L) | 0.005 | 1.005 | 0.997–1.014 | 0.180 |
| CHOL (mg/dL) | 0.010 | 1.010 | 1.001–1.020 | 0.035 |
| LDL (mg/dL) | 0.005 | 1.005 | 0.996–1.015 | 0.273 |
| HDL (mg/dL) | −0.016 | 0.984 | 0.966–1.003 | 0.092 |
| TRIGL (mg/dL) | 0.018 | 1.018 | 1.008–1.028 | <0.001 |
| Hs-CRP (mg/dL)c | 0.625 | 1.868 | 0.916–3.806 | 0.085 |
| GLU (mg/L) | 0.044 | 1.045 | 1.006–1.085 | 0.022 |
| Multivariate logistic regressiona | ||||
| BMI (kg/m2) | 0.245 | 1.277 | 1.080–1.511 | 0.004 |
| Hypertension (yes) | 1.892 | 6.631 | 1.626–27.035 | 0.008 |
Notes: Odds ratio and 95% CI adjusted by the variables (ALT, GGT, CHOL, HDL, TRIGL, and GLU) with P<0.100 in bivariate analysis. BMI and waist circumference were not included in the same model because they are continuous variables with a correlation coefficient higher than 0.7. The same applies to 24-hour mean SBP and daytime mean SBP, 24-hour mean SBP and nighttime mean SBP, and 24-hour mean SBP and morning mean SBP. Upper reference limits are 45 IU/L for AST, 45 IU/L for ALT, 55 IU/L for GGT, 150 IU/L for ALP, 200 mg/dL for CHOL, 140 mg/dL for LDL, 160 mg/dL for TRIGL, 5 mg/L for Hs-CRP, and 110 mg/dL for GLU in our laboratory. Lower reference limit is 35 mg/dL for HDL in our laboratory.
The variable eGFR was transformed using square root;
the variable office SBP was logarithmically transformed;
the variable Hs-CRP was logarithmically transformed.
Abbreviations: B, regression coefficient; OR, odds ratio; CI, confidence interval; BMI, body mass index; eGFR, estimated glomerular filtration rate; SBP, systolic blood pressure; DBP, diastolic blood pressure; AST, aspartate aminotransferase; ALT, alanine aminotransferase; GGT, gamma glutamyl transpeptidase; ALP, alkaline phosphatase; CHOL, cholesterol; LDL, low-density lipoprotein; HDL, high-density lipoprotein; TRIGL, triglycerides; Hs-CRP, high-density c-reactive protein; GLU, glucose serum fast.