Table 2.

Pharmacokinetic parameters

Parameter	Fenofibrate powder	Solid dispersion	Electrosprayed nanospherule
AUC (h·μg/mL)	17.7±3.5	52.0±14.7*	41.0±10.6*
Cmax (μg/mL)	2.4±0.3	5.7±1.8*	5.1±1.6*
Tmax (hour)	1.6±0.2	2.7±1.0	1.8±0.3
t1/2 (hour)	6.1±0.9	6.7±0.3	5.3±1.4

Notes: Each value represents the mean ± standard deviation (n=6). The electrosprayed nanospherule and the solid dispersion were composed of fenofibrate, PVP, and Labrafil M 2125 at the weight ratio of 1:4:0.5.

^*P<0.05 compared with free drug.

Abbreviations: AUC, area under the curve; C_max, maximum plasma concentration; PVP, polyvinylpyrrolidone; T_max, time to reach maximum plasma concentration; t_1/2, half-life of drug.