Table 3.
Genotype and allele distribution of the five polymorphisms, as well as Hardy–Weinberg equilibrium of the controls
| Case (n=439), n (%) | Control (n=524), n (%) | P-valuea | HWEcontrol | |
|---|---|---|---|---|
| rs2243250 | ||||
| TT | 222 (50.6) | 322 (61.5) | 0.001 | χ2=0.810 |
| TC | 171 (39.0) | 173 (33.0) | 0.056 | P=0.360 |
| CC | 46 (10.5) | 29 (5.5) | 0.005 | |
| T allele | 615 (70.0) | 817 (78.0) | <0.001 | |
| C allele | 263 (30.0) | 231 (22.0) | ||
| rs10499563 | ||||
| TT | 301 (68.6) | 310 (59.2) | 0.003 | χ2=0.891 |
| TC | 122 (28.0) | 181 (34.5) | 0.025 | P=0.345 |
| CC | 16 (3.6) | 33 (6.3) | 0.065 | |
| T allele | 724 (82.5) | 801 (76.4) | 0.001 | |
| C allele | 154 (17.5) | 247 (23.6) | ||
| rs4073 | ||||
| TT | 164 (37.4) | 178 (34.0) | 0.274 | χ2=2.306 |
| TA | 201 (45.8) | 240 (45.8) | 0.996 | P=0.129 |
| AA | 74 (16.9) | 106 (20.2) | 0.182 | |
| T allele | 529 (60.3) | 596 (56.9) | 0.134 | |
| A allele | 349 (39.7) | 452 (43.1) | ||
| rs2233406 | ||||
| CC | 319 (72.7) | 401 (76.5) | 0.170 | χ2=0.379 |
| CT | 106 (24.1) | 113 (21.6) | 0.342 | P=0.538 |
| TT | 14 (3.2) | 10 (1.9) | 0.209 | |
| C allele | 744 (84.7) | 915 (87.3) | 0.104 | |
| T allele | 134 (15.3) | 133 (12.7) | ||
| rs3138053 | ||||
| AA | 324 (73.8) | 398 (76.0) | 0.443 | χ2=1.621 |
| AG | 109 (24.8) | 121 (23.1) | 0.529 | P=0.203 |
| GG | 6 (1.4) | 5 (1.00) | 0.551 | |
| A allele | 757 (86.2) | 917 (87.5) | 0.406 | |
| G allele | 121 (13.8) | 131 (12.5) | ||
Notes:
a
Significant at P<0.05. Data in bold indicates statistical significance.
Abbreviation: HWEcontrol, Hardy-Weinberg equilibrium in controls.