Table II.
Effects of amine hydrochloride 1 and bleomycin on TGF-β1 expression in lung tissues.
| Group | Area (μm2) | Integral density |
|---|---|---|
| Normal | 249.09±44.92 | 19.20±10.23 |
| Control | 450.62±56.21a | 86.43±11.04a |
| Prednisone | 306.27±43.63b | 20.03±9.02b |
| 1–5 | 357.66±52.19b | 64.23±8.94b |
| 1–10 | 330.57±67.82b | 45.98±11.02b |
| 1–20 | 268.34±62.24b | 21.01±10.52b |
Normal group, saline + water; control group, bleomycin + water' prednisone group, bleomycin + prednisone at a dose of 5 mg/kg once per day. Groups 1–5, 1–10 and 1–20, bleomycin + 4-methoxyphenethylamine hydrochloride (amine hydrochloride 1) at doses of 5, 10 and 20 mg/kg once per day, respectively. Data are expressed as the means ± SD, n=6 animals per group.
a
p<0.01 vs. normal group;
b
p<0.01 vs. control group. TGF-β1, transforming growth factor-β1.