Table 2.

Change in cognitive function test scores by treatment group

Dose of testosterone enanthate (mg/week)
Cognitive test	Placebo	3 mg	6.25 mg	12.5 mg	25 mg	Dose effect p value
Visual spatial tests
Route learning test (immediate)	0.03 ± 0.23	0.07 ± 0.19	0.06 ± 0.22	−0.006 ± 0.16	0.10 ± 0.25	0.66
Route learning test (delayed)	0.08 ± 0.28	−0.07 ± 0.25	0.15 ± 0.26	−0.05 ± 0.21	0.03 ± 0.26	0.51
Complex figure (immediate)	−0.04 ± 0.12	0.07 ± 0.16	0.11 ± 0.11	0.06 ± 0.10	0.06 ± 0.10	0.34
Complex figure (delayed)	0.04 ± 0.18	0.08 ± 0.14	0.11 ± 0.10	0.11 ± 0.12	0.19 ± 0.21	0.72
Verbal memory tests
Paragraph (immediate)	0.001 ± 0.100	0.03 ± 0.08	0.04 ± 0.06	0.07 ± 0.09	0.04 ± 0.17	0.99
Paragraph (delayed)	0.07 ± 0.10	0.08 ± 0.10	0.13 ± 0.08	0.03 ± 0.19	0.09 ± 0.13	0.30
Buschke (immediate: total correct)	0.08 ± 0.10	0.17 ± 0.10	0.02 ± 0.07	0.18 ± 0.15	0.06 ± 0.04	0.21
Buschke (delayed: total correct)	0.06 ± 0.09	0.20 ± 0.28	0.08 ± 0.12	0.17 ± 0.22	0.01 ± 0.11	0.87
Verbal ability/language tests
Verbal fluency (I)	1.4 ± 6.1	0.33 ± 2.25	1.2 ± 4.4	0.14 ± 3.0	0.00 ± 2.2	0.96
Verbal fluency (K)	2.1 ± 5.1	−0.83 ± 2.32	0.20 ± 4.7	0.86 ± 3.5	−1.4 ± 3.3	0.43
Verbal fluency (P)	2.1 ± 2.7	−0.67 ± 1.37	0.80 ± 6.4	−0.14 ± 4.3	−1.3 ± 4.5	0.68
Category fluency	1.00 ± 8.4	2.5 ± 2.8	2.6 ± 1.9	1.3 ± 4.0	−2.7 ± 4.9	0.78
Attention and executive function tests
VSLT (immediate)	1.2 ± 1.3	2.3 ± 1.4	0.24 ± 1.4	1.8 ± 1.9	0.63 ± 1.1	0.24
VSLT (delayed)	1.5 ± 2.4	−0.14 ± 1.8	0.00 ± 0.71	1.3 ± 2.1	0.43 ± 0.79	0.40
Letter–number sequencing	0.06 ± 0.10	−0.02 ± 0.09	0.01 ± 0.08	−0.03 ± 0.09	0.007 ± 0.06	0.18
Stroop interference test	−9.4 ± 11.1	−7.9 ± 13.5	−3.3 ± 8.9	−6.9 ± 7.0	−3.9 ± 9.3	0.92
Trails B (s)	−4.0 ± 53.4	−17 ± 41	−28 ± 12	−22 ± 19	14 ± 30	0.44
Mazes (s)	23 ± 63	−41 ± 127	29 ± 60	2.0 ± 14.2	−13 ± 85	0.27

Data represent mean ± SD of the change in cognitive test scores from baseline by dose group

The p value displayed represents the significance level of the overall dose effect after adjustment for baseline scores, age, and education

Route learning score reflects change from baseline score out of 16 possible correct items

Complex figure score reflects change from baseline score out of 9 possible correct items

Paragraph recall score reflects change from baseline score out of 44 possible correct items

Buschke immediate and delay scores reflect change from baseline score out of 60 and 12 possible correct items, respectively

Letter–number sequencing score reflects change from baseline score out of 21 possible correct items

VSLT visual spatial learning test