Figure 5. Glutamate release and Gαs-coupled receptor activation are sufficient to rapidly enhance corticostriatal connectivity in brain slices.
(A) Experimental schematic for optogenetic stimulation parameters. (B) Graphic representation of stimulation conditions in the acute slice. (C) Example traces showing average evoked EPSCs for representative neurons in control, stimulation (light+Gαs-coupled receptor agonists) and drugs only conditions. (D) Average amplitudes of optogenetically evoked EPSCs. Left, cumulative distribution of responses in control and stimulated groups. Group averages are shown on the middle and right graphs. Single neurons are represented by circles, error bars reflect SEM.