Table 3.
GO enrichment analysis of proteins regulated by LV in MDA-MB-231 cells
| Category | Count* | % | P Value | Genes |
|---|---|---|---|---|
| Apoptosis | 15(9+6) | 40.5 | 3.41E-06 | DR3, TRADD, Glutamate-cysteine ligase, Caspase 7, Stat1, Raf1, Mek6, Vitamin D3 receptor, Amyloid beta; SODD, PARP, AIF, p63, TGM2, CREB |
| Differentiation | 9(4+5) | 24.3 | 2.77E-06 | Keratin, CD53, ER Ca+2 ATPase II, TTF-1; CD16, CD1a, MHC (HLA-A), B-cell linker protein, CD29 |
| Proliferation | 6(3+3) | 16.2 | 2.77E-06 | p57Kip2, CDC14A, CDC37; CDK4, NuMA, Histone H1 |
| Cell signaling | 8(6+2) | 21.6 | 1.31E-05 | Raf1, Amyloid beta, Mek6, Stat1, myelin-oligodendrocyte glycoprotein, Vitamin D3 receptor; CREB, Gamma glutamyl transferase |
| EMT & metastasis | 7(0+7) | 18.9 | 3.76E-05 | TGM2, HIF-1a, Histone H1, CD50, CD81, CD105, MMP-7 |
*Total count (up- + down-regulated)