Table D.

Multivariate analysis of treatment-related mortality for MDS, by monosomal karyotype

		Relative Risk	P-value
Main effect:
Normal	237	1.00a	Poverall < 0.001
MK positive	219	1.80 (1.27–2.54)	< 0.001
Other unfavorable	416	1.37 (0.99–1.90)	0.06
Intermediate	606	1.01 (0.73–1.39)	0.97
Favorable	97	0.95 (0.59–1.52)	0.83
Other significant covariates:
Age at transplant by conditioning intensity, years
0–20 MA	132	1.00a	Poverall < 0.001
21–40 MA	210	1.62 (1.01–2.58)	0.04
41–60 MA	512	2.30 (1.50–3.54)	< 0.001
41–60 RIC/NMA	277	2.41 (1.53–3.79)	< 0.001
61–64 RIC/NMA	158	2.18 (1.33–3.57)	0.002
> 64 RIC/NMA	113	2.69 (1.56–4.66)	< 0.001
Others	173	2.67 (1.65–4.34)	< 0.001
Karnofsky score
90–100%	1032	1.00a	Poverall = 0.003
< 90%	476	1.40 (1.16–1.70)	< 0.001
Missing	67	1.20 (0.78–1.87)	0.41
HLA matching
HLA-identical sibling	662	1.00a	Poverall < 0.001
Unrelated 8/8	704	1.11 (0.90–1.36)	0.32
Unrelated 7/8	209	1.74 (1.34–2.26)	< 0.001
Disease status at transplant
Early	642	1.00a
Advanced	933	1.30 (1.08–1.58)	0.006
Year of transplant
Continuous	1575	0.91 (0.86–0.96)	< 0.001
Contrast
Main effect MK positive vs. other unfavorable		1.31 (0.98–1.76)	0.07
Main effect MK positive vs. intermediate		1.79 (1.34–2.38)	< 0.001
Main effect MK positive vs. favorable		1.89 (1.22–2.94)	0.005
Main effect other unfavorable vs. intermediate		1.36 (1.08–1.71)	0.009
Main effect other unfavorable vs. favorable		1.44 (0.96–2.17)	0.08
Main effect intermediate vs. favorable		1.06 (0.71–1.58)	0.78
Age 21–40 MA vs. 41–60 MA		0.70 (0.52–0.95)	0.02
Age 21–40 MA vs. 41–60 RIC/NMA		0.67 (0.48–0.94)	0.02
Age 21–40 MA vs. 61–64 RIC/NMA		0.74 (0.50–1.09)	0.13
Age 21–40 MA vs. > 64 RIC/NMA		0.60 (0.38–0.95)	0.03
Age 21–40 MA vs. others		0.61 (0.42–0.88)	0.009
Age 41–60 MA vs. 41–60 RIC/NMA		0.96 (0.73–1.25)	0.74
Age 41–60 MA vs. 61–64 RIC/NMA		1.06 (0.77–1.46)	0.74
Age 41–60 MA vs. > 64 RIC/NMA		0.85 (0.58–1.27)	0.43
Age 41–60 MA vs. others		0.86 (0.63–1.17)	0.34
Age 41–60 RIC/NMA vs. 61–64 RIC/NMA		1.10 (0.77–1.57)	0.58
Age 41–60 RIC/NMA vs. > 64 RIC/NMA		0.89 (0.59–1.36)	0.60
Age 41–60 RIC/NMA vs. others		0.90 (0.64–1.27)	0.55
Age 61–64 RIC/NMA vs. > 64 RIC/NMA		0.81 (0.51–1.28)	0.36
Age 61–64 RIC/NMA vs. others		0.82 (0.56–1.20)	0.30
Age > 64 RIC/NMA vs. others		1.01 (0.65–1.57)	0.97
Karnofsky score < 90% vs. missing		1.17 (0.74–1.83)	0.50
HLA matching 8/8 vs. 7/8		0.64 (0.49–0.83)	< 0.001

^aReference group