Table F.

Multivariate analysis of overall survival for MDS, by monosomal karyotype

		Relative Risk of death	P-value
Main effect:
Normal	241	1.00a	Poverall < 0.001
MK positive	221	2.02 (1.59–2.59)	< 0.001
Other unfavorable	423	1.39 (1.10–1.77)	0.006
Intermediate	611	0.96 (0.76–1.22)	0.73
Favorable	98	1.00 (0.71–1.41)	1.00
Other significant covariates:
Age at transplant by conditioning intensity, years
0–20 MA	132	1.00a	Poverall < 0.001
21–40 MA	212	1.32 (0.93–1.86)	0.12
41–60 MA	519	2.08 (1.52–2.83)	< 0.001
41–60 RIC/NMA	281	2.18 (1.57–3.02)	< 0.001
61–64 RIC/NMA	160	2.05 (1.44–2.91)	< 0.001
> 64 RIC/NMA	116	2.70 (1.83–3.97)	< 0.001
Others	174	2.13 (1.50–3.04)	< 0.001
Karnofsky score
90–100%	1041	1.00a	Poverall < 0.001
< 90%	484	1.40 (1.22–1.62)	< 0.001
Missing	69	1.34 (0.99–1.82)	0.06
HLA matching
HLA-identical sibling	668	1.00a	Poverall < 0.001
Unrelated 8/8	712	1.09 (0.94–1.27)	0.26
Unrelated 7/8	214	1.62 (1.34–1.97)	< 0.001
Disease status at transplant
Early	652	1.00a
Advanced	942	1.45 (1.26–1.67)	< 0.001
Year of transplant
Continuous	1594	0.94 (0.90–0.98)	0.004
Contrast
Main effect MK positive vs. other unfavorable		1.45 (1.19–1.78)	< 0.001
Main effect MK positive vs. intermediate		2.11 (1.73–2.58)	< 0.001
Main effect MK positive vs. favorable		2.02 (1.48–2.78)	< 0.001
Main effect other unfavorable vs. intermediate		1.45 (1.22–1.72)	< 0.001
Main effect other unfavorable vs. favorable		1.39 (1.03–1.88)	0.03
Main effect intermediate vs. favorable		0.96 (0.71–1.29)	0.78
Age 21–40 MA vs. 41–60 MA		0.63 (0.50–0.80)	< 0.001
Age 21–40 MA vs. 41–60 RIC/NMA		0.60 (0.47–0.78)	< 0.001
Age 21–40 MA vs. 61–64 RIC/NMA		0.64 (0.48–0.86)	0.003
Age 21–40 MA vs. > 64 RIC/NMA		0.49 (0.35–0.68)	< 0.001
Age 21–40 MA vs. others		0.62 (0.46–0.82)	0.001
Age 41–60 MA vs. 41–60 RIC/NMA		0.95 (0.79–1.15)	0.62
Age 41–60 MA vs. 61–64 RIC/NMA		1.01 (0.81–1.28)	0.90
Age 41–60 MA vs. > 64 RIC/NMA		0.77 (0.59–1.01)	0.06
Age 41–60 MA vs. others		0.97 (0.77–1.23)	0.82
Age 41–60 RIC/NMA vs. 61–64 RIC/NMA		1.06 (0.83–1.37)	0.63
Age 41–60 RIC/NMA vs. > 64 RIC/NMA		0.81 (0.60–1.08)	0.15
Age 41–60 RIC/NMA vs. others		1.02 (0.79–1.32)	0.86
Age 61–64 RIC/NMA vs. > 64 RIC/NMA		0.76 (0.55–1.04)	0.09
Age 61–64 RIC/NMA vs. others		0.96 (0.72–1.27)	0.78
Age > 64 RIC/NMA vs. others		1.27 (0.92–1.74)	0.14
Karnofsky score < 90% vs. missing		1.05 (0.77–1.43)	0.77
HLA matching 8/8 vs. 7/8		0.67 (0.55–0.81)	< 0.001

^aReference group