Table 2.
Association of severity of villous atrophy with FAS-G670A polymorphism in untreated CD
| Marsh |
Genotype analysis |
Allelic analysis |
|||||
| GG genotype | GA genotype | AA genotype | OR1 (95%CI) | G allele (%) | A allele (%) | OR2 (95%CI) | |
| F/M | F/M | F/M | |||||
| IIIa (%) | 3/3 (15.0) | 17/6 (57.5) | 6/5 (27.5) | Reference | 35 (44.0) | 45 (56.0) | Reference |
| IIIb (%) | 9/5 (21.5) | 25/7 (49.2) | 15/4 (29.2) | 1.63 (0.56-4.76) | 60 (46.0) | 70 (54.0) | 1.10 (0.63-1.93) |
| IIIc (%) | 13/1 (34.1)3 | 18/2 (48.8) | 7/0 (17.1) | 3.74 (1.19-11.82) | 48 (58.5) | 34 (41.5) | 1.81 (0.97-3.38) |
F, women; M, men, OR1, adjusted, for GG genotype frequency;
3
P = 0.025, OR2, adjusted, for G allele frequency.