Table 1. Demographic and clinical details of patients with tumors reclassified according to the IASLC/ATS/ERS classification by the study pathologists (reproduced with permission from the Editor).
Characteristic | Total (N=575) [%] | Observation (surgery alone; n=293) [%] | ACT (n=282) [%] | P* |
---|---|---|---|---|
Sex | 0.18 | |||
Male | 365 [63] | 179 [61] | 186 [66] | |
Female | 210 [37] | 114 [39] | 96 [34] | |
Age, years | 0.56 | |||
<55 | 200 [35] | 101 [34] | 99 [35] | |
55-64 | 216 [38] | 119 [41] | 97 [34] | |
≥65 | 159 [28] | 73 [25] | 86 [31] | |
Stage | 0.87 | |||
I | 310 [54] | 152 [52] | 158 [56] | |
II | 179 [31] | 95 [32] | 84 [30] | |
III | 86 [15] | 46 [16] | 40 [14] | |
N stage | 0.78 | |||
N0 | 325 [57] | 162 [55] | 163 [58] | |
N1 | 174 [30] | 89 [30] | 85 [30] | |
N2 | 76 [13] | 42 [14] | 34 [12] | |
T stage | 0.52 | |||
1 | 88 [15] | 42 [14] | 46 [16] | |
2 | 446 [78] | 230 [79] | 216 [77] | |
3 to 4 | 41 [7] | 21 [7] | 20 [7] | |
Type of surgery | 0.08 | |||
Pneum | 99 [17] | 43 [15] | 56 [20] | |
Other | 476 [83] | 250 [85] | 226 [80] | |
WHO PS | 0.84 | |||
0 | 327 [57] | 162 [55] | 165 [59] | |
1 to 2 | 248 [43] | 131 [45] | 117 [41] | |
Adenocarcinoma subtype | 0.21 | |||
Lepidic | 23 [4] | 13 [4] | 10 [4] | |
Acinar | 148 [26] | 74 [25] | 74 [26] | |
Papillary | 99 [17] | 42 [14] | 57 [20] | |
Micropapillary | 39 [7] | 25 [9] | 14 [5] | |
Solid | 266 [46] | 139 [47] | 127 [45] |
*, χ2 test was calculated from logistic regression model stratified by trial. ACT, adjuvant chemotherapy; ATS, American Thoracic Society; ERS, European Respiratory Society; IASLC, International Association for the Study of Lung Cancer; Pneum, pneumonectomy; PS, performance status.