Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
A general schematic representation of cellular re-sponses to genotoxic stress. Ultraviolet (UV), ionizing radia-tion (IR), and various chemicals can induce DNA damage, such as double strand breaks (DSBs), which can be detected by “sensors”. This generates some signal that can be transduced by the transducers to effector molecules. Finally, there is the presence of an attenuation mechanism to control the cellular response to genotoxic stress.
