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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: Neuropharmacology. 2015 Nov 17;102:197–206. doi: 10.1016/j.neuropharm.2015.11.013

Figure 4. Effects of intra-VTA bicuculline injections on CRF-induced reinstatement.

Figure 4

Data represent responding (lever presses/2-h session ±S.E.) recorded during reinstatement testing following bilateral intra-VTA administration of CRF (500 ng/side) in rats pretreated with intra-VTA injections of vehicle or 1 ng/side (Figure 4A), 10 ng/side (Figure 4B), or 20 ng/side (Figure 4C) concentrations of the GABAA receptor antagonist, bicuculline (BIC), and responding during the previous extinction (Ext) session. Intra-VTA CRF reinstated cocaine seeking regardless of whether rats were pretreated with vehicle or intra-VTA bicuculline (*P<0.05 overall CRF reinstatement effect vs. Ext but no effect of BIC or CRF × BIC interaction).