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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: Neuropharmacology. 2015 Nov 17;102:197–206. doi: 10.1016/j.neuropharm.2015.11.013

Table 1.

Cocaine self-administration and extinction in each group of rats that underwent reinstatement testing.

Intra-VTA
pretreatment group		 Infusions/6-h Session (±S.E.) Responses/2-h
Session (±S.E.)
SA Day 1 SA Day 14 Last Ext Day
Bicuculline (1
ng/side) 		83.75 (±8.66) 92.75 (±14.07) 10.38 (±1.24)
Bicuculline (10
ng/side) 		79.00 (±7.57) 96.00 (±11.48) 14.57 (±3.46)
Bicuculline (20
ng/side) 		61.38 (±7.80) 83.00 (±17.21) 12.50 (±1.76)
2-hydroxysaclofen
(0.2 µg/side) 		70.80 (±3.81) 86.4 (±5.56) 10.20 (±1.56)
2-hydroxysaclofen
(2 µg/side) 		72.22 (±3.27) 82.44 (±4.23) 6.22 (±1.54)

Data represent infusions/6-h session (±S.E.) on days 1 and 14 of self-administration and responses/2-h session (±S.E.) during the final extinction session prior to starting reinstatement testing in separate groups of rats tested for effects of intra-VTA bicuculline (1, 10, or 20 ng/side) or 2-hydroxysaclofen (0.2 or 2 µg/side) on shock and CRF-induced reinstatement.