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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: Neuropharmacology. 2015 Nov 17;102:197–206. doi: 10.1016/j.neuropharm.2015.11.013

Table 2.

Effects of intra-VTA bicuculline or 2-HS injections on food-reinforced lever pressing.

Intra-VTA
Treatment		 Vehicle Bicuculline
(10 ng/side)		 Bicuculline
(20 ng/side)		 2-HS
(0.2 µg/side)		 2-HS
(2 µg/side)
Bas Veh Bas Bic Bas Bic Bas 2-HS Bas 2-HS
Responses/30
minutes 		304.4
(±17.5)		 307.3
(±17.9)		 330.5
(±28.7)		 340.0
(±17.9)		 327.2
(±28.7)		 340.0
(±27.6)		 307.5
(±15.1)		 303.0
(±13.7)		 293.0
(±25.44)		 286.0
(±34.89)

Data represent the numbers of sucrose-sweetened food pellet-reinforced lever presses during the 30-minute session following bilateral intra-VTA injections of vehicle (n=6), 10 ng/side bicuculline (n=4), 20 ng/side bicuculline (n=4), 0.2 µg 2-hydroxysaclofen (n=4), or 2 µg 2-hydroxysaclofen (n=4) or during the preceding baseline session (Bas). Food-reinforced responding was not significantly altered by any of the VTA treatments.