Table 2.
Intra-VTA Treatment |
Vehicle | Bicuculline (10 ng/side) |
Bicuculline (20 ng/side) |
2-HS (0.2 µg/side) |
2-HS (2 µg/side) |
|||||
---|---|---|---|---|---|---|---|---|---|---|
Bas | Veh | Bas | Bic | Bas | Bic | Bas | 2-HS | Bas | 2-HS | |
Responses/30 minutes |
304.4 (±17.5) |
307.3 (±17.9) |
330.5 (±28.7) |
340.0 (±17.9) |
327.2 (±28.7) |
340.0 (±27.6) |
307.5 (±15.1) |
303.0 (±13.7) |
293.0 (±25.44) |
286.0 (±34.89) |
Data represent the numbers of sucrose-sweetened food pellet-reinforced lever presses during the 30-minute session following bilateral intra-VTA injections of vehicle (n=6), 10 ng/side bicuculline (n=4), 20 ng/side bicuculline (n=4), 0.2 µg 2-hydroxysaclofen (n=4), or 2 µg 2-hydroxysaclofen (n=4) or during the preceding baseline session (Bas). Food-reinforced responding was not significantly altered by any of the VTA treatments.