Table 1. Eleven of the 57 independent previously reported coeliac disease signals were nominally significant in the Irish sample.
| Chromosome | Variant ID | Allele | MAFIRISH | ORIrish | PIrish | ORTrynka | PTrynka | Nearest gene |
|---|---|---|---|---|---|---|---|---|
| 4 | rs13132308:g.123770564A>G | G | 0.1686 | 0.614 | 7.45E-04 | 0.7054 | 1.87E-38 | ADAD1, IL2, IL21, KIAA1109 |
| 18 | rs11875687:g.12833137T>C | C | 0.1899 | 1.527 | 1.87E-03 | 1.173 | 1.92E-10 | PTPN2 |
| 3 | rs76830965:g.161120372C>A | A | 0.1595 | 1.547 | 3.06E-03 | 1.36 | 2.56E-27 | SCHIP1, IL12A |
| 12 | rs3184504:g.110368991T>C | T | 0.4914 | 1.391 | 3.41E-03 | 1.192 | 5.42E-21 | ATXN2, SH2B3 |
| 11 | rs61907765:g.127897147C>T | T | 0.2175 | 1.459 | 3.69E-03 | 1.175 | 3.43E-13 | ETS1 |
| 6 | rs1107943:g.159418255T>C | C | 0.07062 | 1.819 | 6.31E-03 | 1.221 | 7.95E-09 | TAGAP |
| 8 | rs10808568:g.129333242A>C | C | 0.2472 | 0.7258 | 1.03E-02 | 0.9132 | 2.20E-05 | PVT1 |
| 11 | rs10892258:g.118085075G>A | A | 0.2275 | 0.7165 | 1.11E-02 | 0.8611 | 1.73E-11 | DDX6, TREH |
| 1 | rs72657048:g.25162321C>G | C | 0.4525 | 0.777 | 2.26E-02 | 0.918 | 3.79E-06 | RUNX3 |
| 4 | rs62323881:g.123257745A>G | A | 0.07973 | 1.568 | 2.98E-02 | 1.204 | 6.87E-08 | ADAD1, IL2, IL21, KIAA1109 |
| 1 | rs1359062:g.190808095C>G | C | 0.1775 | 0.7605 | 5.00E-02 | 0.7691 | 2.55E-25 | RGS1 |
All genomic locations are based on human genome build 18.