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. 2015 Nov 4;15(1):181–186. doi: 10.1111/acel.12415

Figure 1.

Figure 1

Phenotypic characteristics of young and old male Sprague–Dawley rats. (A) Old rats were heavier with more adiposity, (B) but food intake was similar between groups (n = 8 per group). (C,D) Indirect calorimetry confirmed that old animals had greater energy expenditure and lower respiratory exchange ratio during the light and dark photoperiod (n = 8 per group). (E–I) Plasma measures revealed several differences between young and old animals, including old animals having (E) lower glucose, but greater (F) insulin and (G) free fatty acids levels, while (H) insulin‐like growth factor‐1 (IGF‐1) and (I) IGFBP‐3 levels were reduced with aging (n = 12 per group). (J) Western blots of mediobasal hypothalamus tissue detected a slight, but significant decrease in total Akt levels with aging, but no significant differences were observed for total Erk, IGF‐1R, or InsR levels between young and old (n = 12 per group). *P < 0.05, ‡ P < 0.001, # P = 0.06 vs. dark photoperiod.