Table 1.
Representative in vitro and ex-vivo transcriptomic analysis performed with Candida Albicans.
| In vitro condition | Ex vivo condition | Sampling time points | Expression analysis | Number of regulated genesa | Reference |
|---|---|---|---|---|---|
| Shift to serum at 37°C | 30 min, 6 h | Microarray (6580 ORF) | 742 | Nantel et al., 2002 | |
| Heat stress, osmotic stress, oxidative stress | 10, 30, 60 min | Microarray (6580 ORF) | 972 | Enjalbert et al., 2003 | |
| pH shift (pH 4 vs. pH 8) | 4 h | Microarray (6175 ORF) | 1084 | Bensen et al., 2004 | |
| Biofilm formation | 24, 48, 72 h | Microarray (5907 ORF) | 748–856 | Garcia-Sanchez et al., 2004 | |
| Nitric oxide exposure | 10, 40, 70, 120 min | Microarray (6550 ORF) | 131 | Hromatka et al., 2005 | |
| Tetracycline-dependent UME6 expression | 3, 10 h | Microarray (6346 ORF) | 238 | Carlisle and Kadosh, 2013 | |
| Low vs. high iron | 5 h | Microarray (6111 ORF) | 521 | Chen and Noble, 2012 | |
| Spider medium | 8 h | nanoString (293 ORF) | NAb | Finkel et al., 2012 | |
| Human blood | 10, 20, 30, 60 min | Membrane arrays (2002 ORF) | 640 | Fradin et al., 2003 | |
| Human Blood fractions (PMN, MNC, Plasma) | 30 min | Microarray (6039 ORF) | 1518 | Fradin et al., 2005 | |
| Human neutrophils, monocytes | 60, 80 min | Microarray (6550 ORF) | 246 | Rubin-Bejerano et al., 2003 | |
| Murine macropahges | 1, 6 h | Microarray (7600 ORF) | 545 | Lorenz et al., 2004 | |
| Reconstituted human oral epithelium | 1, 3, 6, 12, 24 h | Microarray (6039 ORF) | 164 (upregulated)c | Zakikhany et al., 2007 | |
| Reconstituted human oral epithelium | 30 min | Microarray (6320 ORF) | 268 | Spiering et al., 2010 | |
| Perfused pig liver | 12 h | Microarray (6039 ORF) | 63 | Thewes et al., 2007 | |
| Human oral epithelial cells | 20, 60, 180 min | Microarray (6039 ORF) | 607 | Wächtler et al., 2011 | |
| Murine dendritic cells | 30, 60, 90, 120 min | RNA-seq | 545 | Tierney et al., 2012 | |
| Human epithelial cells | 45, 90, 180 min | Microarray (6266 ORF) | 44–242 | Park et al., 2009 | |
| Human endothelial cells | 45, 90, 180 min | Microarray (6266 ORF) | 54–63 | Park et al., 2009 | |
| Human endothelial cells | 1, 5, 5, 8 h | RNA-seq | 15–31 | Liu et al., 2015 | |
| Human epithelial cell | 1, 5, 5, 8 h | RNA-seq | 21–63 | Liu et al., 2015 |
aInclude genes that are ≥2-fold up- and down-regulated.
bNA, not available.
cOnly upregulated genes were available.