Table 2.
Representative in vivo transcriptomic analysis performed with C. albicans.
| Host | Route of infection | Time points | Organ/tissue/device | Expression analysis | Nucleic acids amplification | Number of regulated genesa | Reference |
|---|---|---|---|---|---|---|---|
| Human | NAb | NA | Oral cavity | Microarray (6039 ORF) | No | 189 (upregulated) | Zakikhany et al., 2007 |
| Neutropenic mice | IV infectionc | 6, 9, 15 h | Kidneys | Microarray (6737 ORF) | No | 652 | Andes et al., 2005 |
| Immuno suppressed mice | OP infectiond | 1, 5 days | Tongue | nanoString (134 ORF) | No | 65 (vs. Spider medium) | Fanning et al., 2012 |
| Mice | IP infectione | 0.5, 3, 5 h | IP space | Microarray (6039 ORF) | Yes | 476 | Thewes et al., 2007 |
| Antibiotic-treated mice | GI infectionf | 3 days | GI tract (cecum) | Microarray (6333 ORF) | No | 440 | Rosenbach et al., 2010 |
| Mice | Central venous catheter | 12, 24 h | Catheter | Microarray (6737 ORF) | No | 545 (12 h) 1034 (24 h) |
Nett et al., 2009 |
| Rabbit | IV infection | 3 days | Kidneys | Microarrays (6580 ORF) | No | 108 | Walker et al., 2009 |
| Zebra fish | IP infection | 0.5–18 h | Whole fish | Microarray (6205 ORF) | No | 120 (0.5–2 h) | Chen et al., 2013 |
| Mice | IP infection | 48 h | IP space | nanoString (145 ORF) | No | NA | Cheng et al., 2013 |
aInclude genes that are ≥2-fold up- and down-regulated.
bNA, not available.
cIntravenous infection.
dOro-pharyngeal infection.
eIntra-peritoneal infection.
fGastro-intestinal infection.